Blockade of Kv1.5 channels by the antidepressant drug sertraline
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چکیده
منابع مشابه
Blockade of Kv1.5 channels by the antidepressant drug sertraline
Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been reported to lead to cardiac toxicity even at therapeutic doses including sudden cardiac death and ventricular arrhythmia. And in a SSRI-independent manner, sertraline has been known to inhibit various voltage-dependent channels, which play an important role in regulation of cardiovascular system. In the present study, we inve...
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The effects of paroxetine, a selective serotonin reuptake inhibitor, on human ether-a-go-go-related gene (HERG) channels were investigated using the whole-cell patch-clamp technique. The HERG channels were stably expressed in human embryonic kidney cells. Paroxetine inhibited the peak tail currents of the HERG channel in a concentration-dependent manner, with an IC50 value of 0.45 µM and a Hill...
متن کاملBlockade of Kv1.5 by paroxetine, an antidepressant drug
Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that paroxetine may cause side effects on cardiac system. In this study, we investigated the effect of paroxetine on Kv1.5, which is one of cardiac ion channels. The action of parox...
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A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 x 10(-6) and 1.20 x 10(-6) mol L(-1). Limits of detection and quantification were found to be 1.5 x 10(-7) and 5.0 x 10 (-7)...
متن کاملBlockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline.
1. Amitriptyline has been known to induce QT prolongation and torsades de pointes which causes sudden death. We studied the effects of amitriptyline on the human ether-a-go-go-related gene (HERG) channel expressed in Xenopus oocytes and on the rapidly activating delayed rectifier K(+) current (I(Kr)) in rat atrial myocytes. 2. The amplitudes of steady-state currents and tail currents of HERG we...
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ژورنال
عنوان ژورنال: The Korean Journal of Physiology & Pharmacology
سال: 2016
ISSN: 1226-4512,2093-3827
DOI: 10.4196/kjpp.2016.20.2.193